Fig. 8.

Antibody avidity was measured as the concentration of NaSCN required to reduce OD₄₀₅ by 50% relative to sample OD₄₀₅ without NaSCN. Vaccination regimes were as described in legend to Fig. 3 with doses as in legend to Fig. 1. Panel A: Avidity 2 weeks after boosting in mice receiving A–M and A–P regimes at 57 day and 97 day dose intervals. Individual values (symbols) and mean (line) are plotted for each group. Panel B: Comparison of avidity between regimes and over time. Arithmetic mean values are plotted for each group. Panel C: Correlation between total IgG ELISA titer and avidity: measurements of total IgG and avidity are plotted for each individual mouse.