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Inhibition of angiogenesis in vivo by granulocyte colony-stimulating factor (G-CSF). There was a reduction of spontaneous vascularization of subcutaneously implanted sponges containing G-CSF in growth-factor-reduced Matrigel as compared with contralateral sponges in the same animal containing growth-factor-reduced Matrigel alone. A P-value of < 0.05 was considered to indicate statistical significance (*P < 0.05; **P < 0.01; ***P < 0.001).
