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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Lancet Infect Dis. 2012 Mar 23;12(6):457–468. doi: 10.1016/S1473-3099(12)70055-5

Figure 3.

Figure 3

Individual and summary incidence rate ratios of P. falciparum syndromes in prospective studies of children with haemoglobinopathies

Abbreviations: CI, confidence interval; Hb, haemoglobin. All incidence rate ratios (IRRs) compare patients with the variant listed to patients with either HbAA or the αα/αα genotype. Summary measures (diamonds) were computed using random-effects Poisson meta-regression of individual studies (squares).

a Studies had overlapping cohorts. Because the cohort in Williams et al (2005)23 subsumes that of Williams et al (2005),24 only data from Williams et al (2005)23 was included in the meta-analyzed summary IRR for uncomplicated malaria in HbAS children.

b Summary IRR of uncomplicated malaria in HbAS compared with HbAA children from five studies.23,34-37

c Summary IRR of uncomplicated malaria in HbAC compared with HbAA children from two studies.35,37

d Summary IRR of uncomplicated malaria in homozygous or heterozygous α-thalassaemic compared with non-thalassaemic children from three studies [Williams 1996, Williams 2005 (NG), Crompton 2008].23,35,39

e Detected by polymerase chain reaction.