Figure 4. Immunofluorescence shows colocalization of Toll-like receptor 4 (TLR4) and von Willebrand’s factor on the vasa rectae of the ischemic inner stripe of the outer medulla (ISOM).
The ischemic kidney was studied at 4 h reperfusion. The same tissue section is shown in all panels, but different input and output light filters were used. Blue is 4,6-diamidino-2-phenylindole. (a) TLR4 visualized with phycoerythrin-conjugated monoclonal rat anti-mouse TLR4 (Santa Cruz, sc 13591). (b) Endothelia visualized with anti-von Willebrand’s antibody and then goat anti-rabbit IgG-Cy3. (c) Overlap of a and b.