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Prolonged time parameters of intracellular Ca2+ transient in transgenic mouse cardiomyocytes. Time to a half peak cytosolic Ca2+ (TP50; A) and time from peak Ca2+ to 75% decay (TR75; B) were longer in the TG vs. WT cardiomyocytes (**P < 0.01, *P < 0.05). Time parameters were effectively shortened by ISO treatment in both groups (++P < 0.01) but were still longer in the transgenic cardiomyocytes (##P < 0.01 compared with the ISO-treated WT control).
