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The effects of metformin are partially restored by the SIRT1 activator SRT2183. A: representative Western blot demonstrating partial restoration of p-AMPK with SRT2183, with no apparent effect on Ac-H3 or Ac-p53. B: triglyceride content in cellular lysates is reported in the graph. C: densitometric analysis of p-AMPK/AMPK. Results are means ± SE (n = 4); *P < 0.05, ***P < 0.001.
