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Nodal treatment upregulates ALK7 and decreases active Akt and X-linked inhibitor of apoptosis (XIAP) expression in INS-1 cells. Western blotting used protein extracts (25 μg) from INS-1 cells treated with Nodal protein as indicated for 24 h (A) or from INS-1 cells transfected with Nodal cDNA for indicated time period (B), using relevant antibodies as indicated and GAPDH as loading controls. Bar graphs show densitometry analysis. Data represent means ± SE; n = 3–5. *P < 0.05, **P < 0.01.
