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PKA targets in myofibers. Some specific substrates include the Na+-K+ pump, phospholemman, LTCC, RyR1, phospholamban (slow-twitch fibers only), glycogen synthetase, phosphorylase kinase, and CREB. Other general cellular processes for which specific targets are not clearly identified are also depicted: nAChR degradation, protein synthesis, the ubiquitin-proteasome pathway, and migration (undifferentiated myoblasts only). This is a partial depiction of PKA substrates.
