Fig. 3.

Effect of chemical chaperones on hepatic expression of genes associated with inflammation and fibrosis in MCD diet-fed mice. A–C: quantitative PCR analysis of TNFα, tissue inhibitor of metalloproteinase-1 (TIMP-1), and matrix metalloproteinase-9 (MMP-9) in C57BL/6J mice fed a MCS or MCD diet with or without TUDCA or PBA for 14 days. Expression is relative to vehicle-injected MCS diet-fed mice. Values are means ± SD (n = 5). *P < 0.05 vs. MCS diet-fed mice treated with the same intraperitoneal injection.