Table 1.
Weight, systolic blood pressure, and serum and urinary cotinine
| Sham | 5/6Nx | 5/6Nx + Nic | 5/6Nx + Nic + MLA | Sham + Nic | Sham + Nic + MLA | 5/6Nx + MLA | |
|---|---|---|---|---|---|---|---|
| Weight at death, g | 431.5 ± 30.0 | 424.3 ± 23.1 | 407.4 ± 20.0 | 327.3.1 ± 12.8*‡ | 398.4 ± 17.0 | 468.4 ± 9.0 | 368.6 ± 11.3*† |
| Systolic blood pressure, mmHg | 135 ± 8.6 | 151 ± 7.1 | 159 ± 7.8* | 148 ± 5.4 | 150 ± 6.8 | 132 ± 11.0‡ | 151 ± 7.1 |
| Serum cotinine, ng/ml | Nondetectable | Nondetectable | 67.2 ± 2.7 | 73.3 ± 2.0 | 55.4 ± 1.0§ | 54.4 ± 0.8§ | Nondetectable |
| Urinary cotinine, μg/day | Nondetectable | Nondetectable | 285.5 ± 31 | 228.6 ± 23 | 719.4 ± 267§ | 532.8 ± 124§ | Nondetectable |
Values are means ± SE.
*
P < 0.05 vs. Sham;
†
P < 0.05 vs. 5/6 nephrectomy (5/6Nx);
‡
P < 0.05 vs. 5/6Nx + nicotine (Nic);
§
P < 0.05 vs. 5/6Nx + Nic and 5/6Nx + Nic + methyllicaconitine (MLA).