Table 2.

Serum creatinine, creatinine clearance, and urinary creatinine, protein excretion, and albumin

	Sham	5/6Nx	5/6Nx + Nic	5/6Nx + Nic + MLA	Sham + Nic	Sham + Nic + MLA	5/6Nx + MLA
Serum creatinine, mg/dl	0.26 ± 0.01	0.62 ± 0.19*	0.51 ± 0.06*	0.26 ± 0.03†‡	0.14 ± 0.02†‡	0.32 ± 0.01#	0.56 ± 0.06*
Creatinine clearance, mg·kg−1·min−1	7.1 ± 0.9	2.7 ± 0.40*	3.8 ± 0.4*	10.3 ± 1.0*†‡	10.6 ± 2.4*†‡	6.2 ± 0.4§	2.7 ± 0.4
Urinary creatinine week 12, mg/day	13.6 ± 1.2	7.7 ± 1.8*	9.6 ± 0.96*	12.9 ± 1.0#	9.8 ± 1.8	11.3 ± 0.8	11.2 ± 1.2
Urinary protein excretion week 12, mg/day	39.1 ± 11.9	122.7 ± 13.6*	162.3 ± 30.3*	91 ± 10*#‡	101 ± 31*‡	131 ± 18*	123.7 ± 22*
Urinary albumin, mg/day	0.54 ± 0.3	3.29 ± 2.0*‡	36.67 ± 13*	13.31 ± 5.6*‡	0.1 ± 0.02‡	0.65 ± 0.3‡	13.5 ± 4.8*‡

Values are means ± SE.

^*P < 0.05 vs. Sham;

^†P < 0.05 vs. 5/6Nx;

^‡P < 0.05 vs. 5/6Nx + Nic;

^§P < 0.05 vs. Sham + Nic.