Figure 3.

Least squares mean change from randomization in Pittsburgh Sleep Quality Index score at (A) week 8 in pooled acute studies (modified intentto- treat; last observation carried forward) and (B) during randomized treatment in the maintenance study (intent-to-treat; last observation carried forward).

Notes: (A) *P < 0.05; ***P < 0.001 vs placebo. n = placebo, quetiapine XR 50, 150, and 300 mg/day, respectively. (B) ***P < 0.001 vs placebo. n = placebo, quetiapine XR, respectively.

Abbreviations: ITT, intent-to-treat; LSM, least squares mean; PSQI, Pittsburgh Sleep Quality Index; XR, extended release.