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. Author manuscript; available in PMC: 2012 Jul 25.
Published in final edited form as: J Immunol. 2011 Apr 11;186(10):5938–5948. doi: 10.4049/jimmunol.1002635

Figure 1. The absence of TLR7-MyD88 signaling delays weight loss, clinical symptoms and virus recovery.

Figure 1

Open symbols/bars represent vehicle-inoculated mice; closed symbols/bars, PVM-inoculated mice. WT mice are represented by circles; TLR7−/− mice by triangles; and MyD88−/− mice by diamonds. (A) Virus recovery (copies of PVM SH gene per 107 copies HPRT) in the lungs of WT, TLR7−/− and MyD88−/− mice was measured by qRT-PCR at 1, 3, 5 and 7 days post inoculation (dpi). (B) WT, (C) TLR7−/− and (D) MyD88−/−mice were weighed at 7 days of age immediately prior to inoculation (day 0) with vehicle or PVM. Mice were weighed every 24 hours thereafter until euthanasia, and weight expressed relative to day 0. Data are mean +/− s.e.m, 4–13 mice in each group and * p<0.05, ** p<0.01, *** p<0.001.