Figure 5. Reactivities of residues in β₂AR featuring ligand-specific conformational rearrangements.

(a–g) bar graphs summarizing the effects of various ligands on the changes in the l-factors of seven different sites of the β₂AR, expressed relative to the receptor without ligand: cys125 (a), lys140 (b), lys227 (c), lys235 (d), lys263 (e), cys265 (f) and lys305 (g). All l-factors shown are for the fast phase except for lys305. l-factor for lys227 is not shown, as no detectable amplitude for the fast phase was observed. data correspond to the means ± standard errors from at least three independent experiments. Asterisks indicate statistical significance (*P < 0.05) compared to control receptor alone by one-way AnovA.