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Effects of CPA on SR Ca2+ release induced by caffeine and norepinephrine in freshly isolated rat distal PASMC
| Peak Δ[Ca2+]i, nM |
|||
|---|---|---|---|
| Stimulus | Control | CPA (10 μM) | P Value |
| Caffeine (30 mM) | 290 ± 94 | −3 ± 2 | <0.04 |
| Norepinephrine (300 μM) | 249 ± 14 | 3 ± 6 | <0.001 |
Values are means ± SE. PASMC, pulmonary arterial smooth muscle cells; CPA, cyclopiazonic acid; SR, sarcoplasmic reticulum; Δ[Ca2+]i, change in intracellular Ca2+ concentration.
