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. 2012 May 25;303(2):L152–L160. doi: 10.1152/ajplung.00116.2012

Fig. 5.

Fig. 5.

Threshold levels of CFTR are necessary for maximal cAMP-stimulated alveolar liquid clearance (ALC) ex vivo. A: ALC was examined in CFTR+/+ (●), CFTR+/− (▲), and CFTR−/− (○) newborn pig lungs under basal and cAMP-stimulated (0.1 mM isoproterenol) conditions. Data are shown as means ± SE; n = 4–6; *P < 0.05 compared with CFTR+/+ and CFTR+/− under stimulated conditions. B: lung wet-to-dry (W/D) weight ratio was used as an index of lung liquid accumulation in CF (CFTR−/−) and non-CF (including CFTR+/+ and CFTR+/−) newborn piglets. W/D weight ratio was calculated by dividing the wet by the dry weight as described previously (22). Data are shown as means ± SE; n = 5.