Table 2.
Indices of trabecular and cortical bone formation and resorption measured in the distal femoral metaphysis and middiaphysis at time of death (34 wk)
| Values at Time of Death |
||||
|---|---|---|---|---|
| Control | 1x-HLU | 2x-HLU | 3x-HLU | |
| Metaphysis | ||||
| Trabecular | ||||
| MS/BS, % | 2.9 ± 1.0 | 2.7 ± 0.84 | 2.1 ± 1.0 | 2.1 ± 0.67 |
| MAR, μm/day | 0.31 ± 0.17 | 0.23 ± 0.21 | 0.16 ± 0.14 | 0.06 ± 0.07a |
| BFR/BS × 10−3, | 11 ± 9.1 | 6.4 ± 6.8 | 3.9 ± 3.8 | 1.8 ± 2.3a |
| μm3•μm−2•day−1 | ||||
| Oc.S/BS, % | 13 ± 4.5 | 15 ± 4.1 | 18 ± 2.8 | 16 ± 5.6 |
| # Without Double Label | 0 | 3 | 3 | 5 |
| Diaphysis | ||||
| Endocortical | ||||
| MS/BS, % | 9.1 ± 5.0 | 16 ± 10 | 9.4 ± 9.3 | 14 ± 3.5 |
| MAR, μm/day | 0.22 ± 0.13 | 0.15 ± 0.16 | 0.17 ± 0.18 | 0.30 ± 0.24 |
| BFR/BS × 10−3, | 22 ± 20 | 26 ± 27 | 28 ± 48 | 44 ± 30 |
| μm3•μm−2•day−1 | ||||
| Oc.S/BS, % | 15 ± 7.9 | 13 ± 5.9 | 16 ± 10.9 | 12 ± 8.2 |
| # Without Double Label | 1 | 1 | 2 | 1 |
| Periosteal | ||||
| MS/BS, % | 3.7 ± 6.1 | 13 ± 10 | 7.3 ± 5.2 | 11 ± 12 |
| MAR, μm/day | 0.08 ± 0.11 | 0.12 ± 0.08 | 0.14 ± 0.17 | 0.19 ± 0.19 |
| BFR/BS × 10−3, | 8.5 ± 18 | 20 ± 21 | 17 ± 29 | 26 ± 25 |
| μm3•μm−2•day−1 | ||||
| Oc.S/BS, % | 0.00 ± 0.00 | 0.31 ± 0.58 | 0.52 ± 1.0 | 0.32 ± 0.72 |
| # Without Double Label | 4 | 2 | 2 | 2 |
Data are shown as means ± SD. Groups were compared using ANOVA followed by SNK. Letters denote significant differences (P < 0.05) between groups. aAny group different from control. MS/BS, % mineralizing surface; MAR, mineralization apposition rate; BFR/BS, bone formation rate; Oc.S/BS, osteoclast surface.