Table 3.
Comparison of characteristics in women with preeclampsia and the model of RUPP in the rat
| Characteristic | Women with Preeclampsia | RUPP in Rats | Ref. No. |
|---|---|---|---|
| New-onset hypertension | Yes | Yes | 11 |
| Abnormal placentation | Yes | No | 42, 45, 82, 83 |
| Proteinuria | Yes | Yes | 11 |
| Renal plasma flow | Dec | Dec | 90 |
| GFR | Dec | Dec | 11 |
| Inflammation (TNF-α, IL-6, CD4+ T cells) | Inc | Inc | 30, 59, 99 |
| Oxidative stress | Inc | Inc | 88 |
| Endothelin-1 | Inc | Inc | 33 |
| sFlt-1 | Inc | Inc | 35 |
| VEGF, PIGF | Dec | Dec | 35 |
| Soluble endoglin | Inc | Inc | 37 |
| Placental HIF-1α | Inc | Inc | 37 |
| AT1-AA | Inc | Inc | 58 |
| Glomerular endotheliosis | Yes | No | 62 |
| Podocyte shedding | Yes | 6, 31 | |
| HELLP syndrome | In severe cases | No | 48 |
| Fetal IUGR | Yes | Yes | 7, 52 |
TNF-α, tumor necrosis factor-α; IL-6, interleukin-6; PIGF, placental growth factor; HIF-1α, hypoxia-inducible factor-1α; AT1-AA, agonistic autoantibodies against angiotensin type 1 receptor; HELLP syndrome, hemolysis, elevated liver enzymes, low platelets.