Table 1.
Baseline cardiac parameters in ex vivo perfused hearts from WT and mTOR-Tg mice
| WT Mice | mTOR-Tg Mice | P Value | |
|---|---|---|---|
| Body weight, g | 25.1 ± 0.6 | 24.0 ± 0.6 | 0.226 |
| Heart weight/tibia length, mg/mm | 5.8 ± 0.3 | 5.4 ± 0.1 | 0.158 |
| LV systolic pressure, mmHg | 121 ± 5 | 131 ± 6 | 0.208 |
| LV end-diastolic pressure, mmHg | 5.3 ± 0.3 | 5.8 ± 0.6 | 0.375 |
| LV developed pressure, mmHg | 116 ± 5 | 125 ± 6 | 0.224 |
| LV dP/dtmax, mmHg/s | 4,794 ± 197 | 4,835 ± 251 | 0.895 |
| LV dP/dtmin, mmHg/s | −2,624 ± 95 | −2,532 ± 109 | 0.533 |
| Coronary flow, ml/min | 2.7 ± 0.2 | 2.4 ± 0.2 | 0.212 |
Values are means ± SE; n = 28 wild-type (WT) mice and 19 mammalian target of rapamycin (mTOR) transgenic (mTOR-Tg) mice. LV, left ventricular; LV dP/dtmax and LV dP/dtmin, maximum and minimum first derivatives of LV pressure.