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Food intake (A) and body weight (B) in AT1aR−/− (n = 5) and AT1aR+/+ (n = 7) mice at baseline (day 1) and with daily ICV injections of leptin (2 μg; days 2–4). Leptin produced a significant decrease (P ≤ 0.05) in food intake and in body weight in both AT1aR−/− and AT1aR±/±, but there was no significant difference in these responses between AT1aR−/− and AT1aR±/±.
