Table 3.

Time course of hemodynamic responses after ICV leptin in rats pretreated with captopril

	Time After Treatment, min
Pretreatment/Treatment	Baseline	60	120	180	240
MAP, mmHg
Saline/leptin (6)	94 ± 3	100 ± 4	102 ± 5	100 ± 4	97 ± 5
Captopril/leptin (6)	100 ± 6	94 ± 3	96 ± 3	96 ± 6	96 ± 6
Captopril/saline (6)	105 ± 11	114 ± 8	113 ± 9	114 ± 11	110 ± 11
HR, beats/min
Saline/leptin (6)	378 ± 19	386 ± 5	391 ± 9	393 ± 11	398 ± 10
Captopril/leptin (6)	397 ± 9	377 ± 5	393 ± 14	392 ± 5	409 ± 8
Captopril/saline (6)	367 ± 11	370 ± 11	385 ± 13	391 ± 13	402 ± 18

Values are means ± SE; nos. in parenthesis equal no. of rats.