Table 3.
Demographic, Behavioral, and Clinical Correlates of Participants With High Discordance Compared to Concordant Participants
| Characteristic | Univariate analysis |
Multivariable analysis |
|
|---|---|---|---|
| Crude OR (95% CI) |
Model 1 |
Model 2 |
|
| All |
TLC ≤1200 cells/μL |
||
| AOR (95% CI) |
AOR (95% CI) |
||
| N = 287 | n = 233 | n = 114 | |
| Demographic | |||
| Age (per y) | 0.98 (.95–1.02) | 0.98 (.94–1.02) | 1.03 (.96–1.10) |
| Female | 0.85 (.50–1.46) | 0.80 (.45–1.41) | 0.88 (.38–2.03) |
| Black | 0.47 (.16–1.36) | 0.52 (.17–1.56) | …a |
| Behavioral | |||
| Any injection drug useb | 0.85 (.50–1.43) | … | … |
| Alcohol useb | |||
| None | Ref | … | … |
| Weekly | 1.35 (.78–2.35) | … | … |
| Daily | 1.82 (.71–4.70) | … | … |
| Hematologic | |||
| Platelets | 0.87 (.6–1.27) | … | … |
| HIV-related | |||
| HIV RNA >400 copies/mL | 0.94 (.55–1.58) | … | … |
| HAART useb | 0.95 (.56–1.27) | … | … |
| Liver-related | |||
| AST | 1.00 (1.00–1.01) | … | … |
| ALT | 1.00 (.99–1.01) | … | … |
| HCV Ab positive | 0.98 (.33–2.93) | … | … |
| HBsAg positive | 1.13 (.34–3.83) | … | … |
| LSM ≥9.3 kPa | 1.62 (.93–2.84) | 1.68 (.95–2.96) | 2.66 (1.11–6.40) |
High discordance: where CD4 cell percentage measures high relative to the absolute CD4 cell count. There were 134 persons in the concordant group and 99 in the high discordance group.
Abbreviations: ALT, alanine aminotransferase; AOR, adjusted odds ratio; AST, aspartate aminotransferase; CI, confidence interval; HAART, highly active antiretroviral therapy; HBsAg, hepatitis B virus surface antigen; HCV Ab, hepatitis C virus antibody; HIV, human immunodeficiency virus; LSM, liver stiffness measurement by elastography; OR, odds ratio; TLC, total lymphocyte count.
a Dropped due to inestimability as all patients in this group were black.
b In the preceding 6 months.