Table 2.

Clinical and pathological characterization of cases of Alzheimer disease without hippocampal TDP-43 NCIs. All cases of hippocampal-negative cases also had negative TDP-43 immunoreactivity in the frontal, temporal, and parietal cortical regions.

TDP-43 Pattern of Distribution	Patient	Age of Death	Primary Clinical Diagnosis	Secondary Clinical Diagnosis	Braak Staging	Amygdala TDP-43	Entorhinal Cortex
Amygdala Only	101	87	AD		5	1+	0
	102	79	AD		6	3+	0
	103	82	AD	Depression	6	3+	0.5+
	104	98	AD		6	3+	1+
	105	95	AD		5	3+	1+
	106	79	AD		5	3+	3+
None	107	94	AD	Depression	6	0	0
	108	91	AD		6	0	0
	109	89	AD	B12 deficiency	6	0	0
	110	86	AD		6	0	0
	111	85	AD		6	0	0
	112	83	AD		6	0	0
	113	80	AD	Depression	6	0	0
	114	79	AD	Depression	6	0	0
	115	66	AD	DLB	6	0	0
	116	91	AD		5	0	0
	117	89	AD		5	0	0
	118	88	Multi-infarct dementia		5	0	0
	119	87	AD		5	0	0
	120	86	AD	Single stroke	5	0	0
	121	81	AD		5	0	0
	122	79	Multi-infarct dementia		5	0	0

(AD = probable Alzheimer disease; aMCI = amnestic mild cognitive impairment; DLB = dementia with Lewy bodies)