Table 1.

The 20 most significant GWAS findings based on the allelic transmission disequilibrium test. Shown are chromosome and SNP “RS” number, gene or region name, and its respective position. Also listed are the number of times the major allele was transmitted (T) or not transmitted (U) from a heterozygous parent to the offspring. The respective odds ratios, test statistics, and p-values (based on an asymptotic ${\chi }_1^2$ distribution) are also shown. The complete findings are listed in the supplementary material of Beaty et al. (2010).

Chr	SNP	Gene/region	Position	T	U	OR	χ 2	p
8	RS987525	hCG 1814486*	130015336	554	311	1.78	68.3	1.4E-16
11	RS1784394**	JAM3	133468426	84	228	0.37	66.5	3.6E-16
1	RS10863790	IRF6	208054670	312	538	0.58	60.1	9.1E-15
8	RS1519847	hCG 1814486	129984942	670	430	1.56	52.4	4.6E-13
8	RS882083	hCG 1814486	130051938	616	393	1.57	49.3	2.2E-12
8	RS12542837	hCG 1814486	129995843	668	435	1.54	49.2	2.3E-12
1	RS560426	ABCA4	94326026	885	618	1.43	47.4	5.7E-12
8	RS1519841	hCG 1814486	129988982	668	440	1.52	46.9	7.4E-12
8	RS12548036	hCG 1814486	130017064	628	408	1.54	46.7	8.2E-12
20	RS13041247	MAFB	38702488	620	881	0.70	45.4	1.6E-11
20	RS11696257	MAFB	38704230	621	881	0.71	45.0	2.0E-11
8	RS1530300	hCG 1814486	129988640	530	333	1.59	45.0	2.0E-11
1	RS2013162	IRF6	208035307	620	879	0.71	44.8	2.2E-11
20	RS17820943	MAFB	38701930	620	877	0.71	44.1	3.1E-11
1	RS2073485	IRF6	208029417	513	745	0.69	42.8	6.1E-11
8	RS1850889	hCG 1814486	129959587	288	465	0.62	41.6	1.1E-10
8	RS1519850	hCG 1814486	129966003	251	415	0.61	40.4	2.1E-10
8	RS7017252	hCG 1814486	130020026	560	367	1.53	40.2	2.3E-10
8	RS11787407	hCG 1814486	130054622	604	404	1.50	39.7	3.0E-10
8	RS1470206	hCG 1814486	130046646	661	452	1.46	39.3	3.7E-10

^*gene desert region of 8q24;

^**SNP showed poor clustering even though it was not flagged in quality control process.