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. Author manuscript; available in PMC: 2013 Apr 2.
Published in final edited form as: Mol Pharm. 2012 Mar 16;9(4):862–873. doi: 10.1021/mp200400s

Figure 2. Sulfonation of flavonoids by expressed human SULT1A3 (left three panels) and Caco-2 cell lysates (right three panels).

Figure 2

Flavonoids were from 5 apigenin analogs representing five sub-classes of flavonoids (A, D), 6 flavones (B. E), and 6 flavonols (C, F). Experiments were conducted at the concentration of 2.5 µM (open column) and 10 µM (solid column). Amounts of mono-sulfate(s) formed were measured using UPLC, and quantified using the correction factors shown in Table 2. Rates of sulfonation were calculated as nmol/min/mg of protein. Each bar is the average of three determinations, and the error bars are the standard deviations of the mean (n=3).