Table 3.
Baseline predictors of change in BMI (kg/m2) among HIV-negative TB patients from initiation to end of TB treatment (8 months) and post-treatment (14 months after baseline).
| Baseline predictors | N (%) | BMI at baseline1 | Change in BMI from 0 to 8 months (n = 314)
|
Change in BMI from 0 to 14 months (n = 252)
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Change from 0 to 8 months | Adjusted difference (95% CI)2 | p | p, test for trend3 | Change from 0 to 14 months | Adjusted difference (95% CI)2 | p | p, test for trend3 | |||
| Sex | ||||||||||
| Male | 317 (76.2%) | 18.7 ± 0.1 | 2.7 ± 0.1 | Reference | 2.5 ± 0.1 | Reference | ||||
| Female | 99 (23.8%) | 19.4 ± 0.3 | 3.0 ± 0.2 | 0.3 (−0.2, 0.8) | 0.22 | 3.3 ± 0.3 | 0.8 (0.1, 1.5) | 0.02 | ||
| Age | 0.79 | 0.03 | ||||||||
| < 30 years | 241 (57.9%) | 18.7 ± 0.2 | 2.8 ± 0.1 | Reference | 2.6 ± 0.2 | Reference | ||||
| 30 – 39 years | 112 (26.9%) | 19.2 ± 0.2 | 2.7 ± 0.2 | −0.2 (−0.7, 0.6) | 0.38 | 2.4 ± 0.3 | −0.5 (−1.2, 0.2) | 0.17 | ||
| ≥ 40 years | 63(15.1%) | 19.2 ± 0.4 | 2.8 ± 0.3 | −0.1 (−0.7, 0.6) | 0.86 | 3.4 ± 0.3 | 0.6 (−0.2, 1.4) | 0.12 | ||
| Marital status | ||||||||||
| Married | 179 (43.0%) | 19.1 ± 0.2 | 2.9 ± 0.2 | Reference | 3.1 ± 0.2 | Reference | ||||
| Cohabiting | 29 (7.0%) | 19.5 ± 0.5 | 3.0 ± 0.3 | 0.0 (−0.7, 0.7) | 0.96 | 2.4 ± 0.7 | −0.6 (−2.4, 1.1) | 0.48 | ||
| Single | 175 (42.1%) | 18.5 ± 0.2 | 2.6 ± 0.2 | −0.4 (−0.9, 0.1) | 0.13 | 2.3 ± 0.2 | −0.8 (−1.4, −0.2) | 0.01 | ||
| Divorced/widowed | 33 (7.9%) | 19.2 ± 0.5 | 2.2 ± 0.4 | −0.8 (−1.6, 0.1) | 0.07 | 2.4 ± 0.7 | −0.6 (−2.4, 1.1) | 0.12 | ||
| CD4 count | 0.22 | 0.08 | ||||||||
| < 750 cells/mm3 | 236 (64.0%) | 19.0 ± 0.2 | 2.8 ± 0.1 | 0.3 (−0.4, 0.8) | 0.19 | 3.0 ± 0.2 | 0.6 (0.0, 1.2) | 0.06 | ||
| ≥ 750 cells/mm3 | 133 (36.0%) | 18.8 ± 0.2 | 2.6 ± 0.2 | Reference | 2.3 ± 0.3 | Reference | ||||
| Karnofsky performance score | 0.02 | 0.04 | ||||||||
| ≥ 70% | 384 (92.5%) | 19.0 ± 0.1 | 2.7 ± 0.1 | Reference | 2.6 ± 0.1 | Reference | ||||
| < 70% | 31 (7.5%) | 17.1 ± 0.3 | 3.3 ± 0.3 | 0.5 (0.0, 1.1) | 0.05 | 3.6 ± 0.5 | 1.1 (0.1, 2.0) | 0.03 | ||
Footnotes for Table 3.
1
Mean ± SE for all such value.
2
Adjusted differences in change in BMI were estimated from the multivariate linear regression model that includes sex, age, marital status, CD4 cell counts, Karnofsky performance score, and treatment assignment. Other variables were not associated with change in BMI in univariate analysis (p> 0.20).
3
P-value for test for trend was obtained from median values within quartiles. Karofsky score was entered as a continuous variable.