Table 1.
Limiting dilution analysis for tumor incidence of CSCs in nude mice.
| Strain | Population | Number of tumors/number of injections |
CSC frequency (95% confidence interval) | ||||
|---|---|---|---|---|---|---|---|
| Cells per injection | |||||||
| 10,000 | 1,000 | 100 | 10 | ||||
| MB231 | Unsorted | 2/4 | 1/4 | 0/2 | 1/10,720 | (1/3,203-1/35,879) | |
| Stem cells | 6/6 | 5/6 | 2/6 | 1/448**/$$ | (1/183-1/1,097) | ||
| Non-stem cells | 1/2 | 0/2 | 0/2 | 1/16,705 | (1/2,356-1/118,284) | ||
|
| |||||||
| 231BoM | Unsorted | 6/6 | 6/7 | 3/5 | 0/3 | 1/334 | (1/140-1/844) |
| Stem cells | 5/5 | 11/11 | 9/11 | 6/11 | 1/37**/$$ | (1/19-1/72) | |
| Non-stem cells | 2/4 | 0/4 | 0/4 | 1/1,671 | (1/419-1/6,668) | ||
|
| |||||||
| 231BrM | Unsorted | 4/4 | 1/4 | 0/4 | 1/277 | (1/86-1/895) | |
| Stem cells | 4/4 | 5/6 | 2/6 | 1/45*/$$ | (1/19-1/110) | ||
| Non-stem cells | 5/6 | 1/6 | 0/6 | 1/569 | (1/236-1/1374) | ||
*
: P<0.05 (Unsorted vs stem cells)
**
: P<0.0001 (Unsorted vs stem cells)
$$
: P<0.0001 (Non-stem cells vs stem cells)