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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Nanomedicine (Lond). 2012 Feb 23;7(4):521–539. doi: 10.2217/nnm.11.158

Figure 1. Vector design and transmission electron microscopy of dNA nanoparticles formulated with acetate.

Figure 1

(A) Maps of the circular and (B) linear eGFP expression cassettes containing 292 and 75 CpG dinucleotides, respectively. (C) Transmission electron microscopy of circular eGFP and (d) linear eGFP nanoparticles. The presence of acetate as the lysine counterion during the compaction procedure produces rod-shaped nanoparticles with minor diameters ranging from 8 to 11 nm. Magnification is 40,000. eGFP: Enhanced GFP.