Table 1.
Accuracy and Precision of the CTC detection method
| Expected CTC count |
N |
N |
Observed CTC count |
% Recovery |
|||||
|---|---|---|---|---|---|---|---|---|---|
| donors | samples | Mean | SD | 95% CI | Mean | SD | 95% CI | % CV | |
| 10 |
2 |
6 |
8 |
2.4 |
6–10 |
80 |
24 |
55–105 |
30 |
| 30 |
3 |
8 |
25 |
3 |
22–27 |
82 |
10 |
74–90 |
12 |
| 85 |
3 |
8 |
76 |
14 |
65–88 |
90 |
16 |
76–104 |
18 |
| 185 |
2 |
6 |
151 |
18 |
131–171 |
82 |
10 |
71–92 |
12 |
| TOTAL | 5 | 28 | 84 | 15 | 78–90 | 18 | |||
Observed vs. expected numbers of CTCs and recovery measured in blood samples of 5 healthy donors spiked with defined numbers of HCC1937 tumor cells.SD = standard deviation, CI = confidence interval of the mean, CV = coefficient of variation (SD/mean).