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. 2012 Jul 25;7(7):e41686. doi: 10.1371/journal.pone.0041686

Figure 4. Effect of extracellular C18-CAR on hERG activation and availability.

Figure 4

A. Activation curve in PSS (squares): V½  =  −20.3±0.1 mV (n = 10); in the presence of 1 µM C18-CAR (circles): −22.8±0.1 mV (n = 8); in the presence of 3 µM C18-CAR (diamonds): −30.0±0.3 mV (n = 8) and in the presence of 10 µM C18-CAR (triangles): −31.9±0.9 mV (n = 4). B. Availability curve in PSS (squares): V½  =  −40.9±2.3 mV (n = 8); in the presence of 1 µM C18-CAR (circles): V½ =  −36.2±3.1 mV (n = 8); in the presence of 3 µM C18-CAR (triangles): V1/2 =  −34.8±1.4 mV (n = 8) and in the presence of 10 µM C18-CAR (diamonds): V1/2 =  −35.6±2.1 mV.