Table 2. Associations of CFH genetic variants with blood pressure and hypertension in Chinese Hans.
| SNP | Risk allele/Alternative | RAF | DBP(mmHg) | SBP(mmHg) | HTN | |||||
| RAF | OR (95%CI) | P | ||||||||
| β(SE) | P | β(SE) | P | Case = 1781 | Control = 550 | |||||
| rs1061170 (Y402H)a | C/T | |||||||||
| Beijing (n = 1558) | 0.071 | 1.334(0.880) | 0.130 | 2.283(1.740) | 0.19 | 0.073 | 0.068 | 1.004(0.602–1.673) | 0.989 | |
| Shanghai (n = 1612) | 0.047 | −0.046(1.034) | 0.964 | 0.581(1.978) | 0.769 | 0.047 | 0.050 | 1.045(0.655–1.669) | 0.853 | |
| Allb (n = 3170) | 0.059 | 0.754(0.670) | 0.303 | 1.541(1.306) | 0.259 | 1.026(0.727–1.449) | 0.887 | |||
| P (heter) | 0.309 | 0.518 | 0.908 | |||||||
| rs2274700 (A473A) | T/C | |||||||||
| Beijing (n = 1544) | 0.442 | 0.214(0.433) | 0.621 | 1.427(0.855) | 0.095 | 0.449 | 0.427 | 1.141(0.893–1.460) | 0.292 | |
| Shanghai (n = 1584) | 0.420 | 1.044(0.430) | 0.015 | 1.698(0.825) | 0.040 | 0.432 | 0.400 | 1.197(0.978–1.466) | 0.081 | |
| Allb (n = 3128) | 0.431 | 0.632(0.305) | 0.038 | 1.567(0.594) | 0.008c | 1.175(1.005–1.373) | 0.048 | |||
| P (heter) | 0.174 | 0.820 | 0.770 | |||||||
| rs7542235 ( CFHR1–3 Δ) a | G/A | |||||||||
| Beijing (n = 1544) | 0.076 | 0.681(0.858) | 0.428 | 4.211(1.696) | 0.013 | 0.079 | 0.070 | 1.284(0.774–2.131) | 0.334 | |
| Shanghai (n = 1584) | 0.067 | 2.239(0.891) | 0.012 | 4.684(1.712) | 0.006c | 0.072 | 0.060 | 1.180(0.776–1.795) | 0.439 | |
| Allb (n = 3128) | 0.072 | 1.431(0.618) | 0.019 | 4.445(1.205) | 0.0002c | 1.221(0.884–1.687) | 0.219 | |||
| P (heter) | 0.208 | 0.844 | 0.801 | |||||||
β (SE) and OR (95%CI) were expressed as changes in blood pressure and odds of hypertension for increasing copy of risk alleles in Beijing, Shanghai and total population (All). P values were adjusted for age, sex and BMI.
a
Dominant model was applied, otherwise additive model was used.
b
β (SE) and OR (95%CI) were calculated using an inverse-variance weighted (fixed effect) meta-analysis and P values were calculated using a z-score weighted approach.
c
The associations remained significant after Bonferroni correction for multiple tests (the Bonferroni corrected cutoff P value was 0.05/6 = 0.0083). RAF: Risk Allele Frequency, SBP: Systolic Blood Pressure, DBP: Diastolic Blood Pressure, HTN: Hypertension, P (heter) : P for heterogeneity.