Table 3. Associations of CFH genetic variants genotypes with blood pressure and hypertension stratified by C-reactive protein levels.

SNP genotype	DBP (mmHg)		SBP (mmHg)		Hypertension
	Mean ± SE	P	Mean ± SE	P	OR(95%CI)	P
rs1061170 (Y402H)
Low CRP levels (<2.0 mg/l, n = 2607)
TT	82.43±0.25		142.89±0.49		1.00 (reference)
CT + CC	82.99±0.71		144.11±1.38		1.00 (0.69–1.45)
Dominant	0.59 (0.75)	0.4304	1.13(1.46)	0.4383	1.00 (0.69–1.45)	0.9930
Elevated CRP levels (≥2.0 mg/l, n = 603)
TT	86.59±0.55		150.89±1.09		1.00 (reference)
CT + CC	87.81±1.39		153.30±2.75		1.01 (0.37–2.74)
Dominant	1.22 (1.46)	0.4049	2.16(2.85)	0.4487	1.01 (0.37–2.74)	0.9891
P for interaction		0.8126		0.7867		0.7579
rs2274700 (A473A)
Low CRP levels (<2.0 mg/l, n = 2607)
CC	81.28±0.42		140.21±0.81		1.00 (reference)
CT	82.94±0.33		144.04±0.64		1.42 (1.09–1.84)
TT	83.15±0.55		145.00±1.07		1.22 (1.03–1.45)
Additive	1.04 (0.34)	0.0021	2.58 (0.66)	0.00008	1.26 (1.06–1.49)	0.0079
Elevated CRP levels (≥2.0 mg/l, n = 603)
CC	86.69±0.86		151.78±1.69		1.00 (reference)
CT	87.67±0.74		152.52±1.45		1.44 (0.69–3.02)
TT	84.12±1.16		145.39±2.27		0.74 (0.49–1.11)
Additive	−0.95 (0.70)	0.1903	−2.46 (1.36)	0.0807	0.82 (0.53–1.25)	0.3352
P for interaction		0.0110		0.0010		0.0467

Data are means ± SE, OR (95%CI) or β (SE). β (SE) and OR (95%CI) were calculated using an inverse-variance weighted (fixed effect) meta-analysis and P values were calculated using a z-score weighted approach. P for interaction was calculated using general linear regression after adjusting for age, sex and BMI.