Figure 1. IKZF1 deletion patterns in adult ALL patients.

Schematic representation of the IKZF1 gene on chromosome 7p12, with coding exons (ex) in gray and the first non-coding exon in white. N-terminal zinc-fingers (F1–F4) show DNA-binding activity and C-terminal ones (F5–F6) mediate dimerization of the protein. Black segment reports indicate the genomic extent of the IKZF1 deletions of the most common deletions. Percentage is reported for each type of deletion.