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. 2012 Jul 25;7(7):e41858. doi: 10.1371/journal.pone.0041858

Figure 2. Minocycline promoted corneal epithelial recovery after alkali burns.

Figure 2

(A) Representative images of the mice corneas with fluorescein staining with intraperitoneal injection of minocycline or PBS after alkali burns. (B) The area of epithelial defect in the minocycline-treated groups was significantly smaller than that in the control group. The percentages of corneal epithelial defect in the control group, the low-dosage group, and the high-dosage group were 20.92%±8.77%, 18.62%±5.83% and 11.19%±7.14% on day 4; 16.13%±3.63%, 11.41%±4.47% and 6.02%±3.56% on day 7; 10.40%±4.09%, 6.42%±3.50% and 1.11%±1.24% on day 10; 4.84%±2.58%, 1.85%±1.80% and 0% on day 14, respectively. (*p<0.05,**p<0.01, ***p<0.001).