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. 2012 Jul 25;7(7):e42105. doi: 10.1371/journal.pone.0042105

Figure 6. Loperamide produces a conduction blockade in A and C fibers in the peripheral nerve.

Figure 6

The A-CAPs (blue circles) changed significantly with different incubation steps (Friedman ANOVA, p<0.001). After incubation with the highest loperamide dose, the A-CAP was significantly reduced compared to A-CAP under CDEX (10th min) (**p<0.01, Wilcoxon-matched pairs with correction for multiple testing). The C-CAP (red circles) also changed significantly during the course of the experiment (Friedman ANOVA, p<0.001). Under loperamide (5 and 10 µg/10 µl), the C-CAP significantly decreased compared to CDEX C-CAP (**p<0.01, Wilcoxon-matched pairs with correction for multiple testing). At the lowest loperamide concentration (2 µg/10 µl), the C-CAP was significantly smaller than the A-CAP (#p<0.05 Mann Whitney U test).