Figure 8. Naloxone does not prevent the conduction blockade effects of loperamide.

The nerve was preincubated with naloxone (4 µg/10 µl) for 5 minutes followd by incubation with loperamide (5 µg/10 µl for 10 min). Preincubation with naloxone did not prevent loperamide induced changes of A- and C- CAPs (p<0.001, repeated measures ANOVA). Incubation with loperamide significantly reduced A-CAP and C- CAP compared to 5 min SIF incubation (**p<0.01, *p<0.05, paired t-test, n = 8).