Table 5. Addition of family history information to genetic risk scores.
NRI | IDI | ||||
Value | SE | p | Value | p | |
FRS+FH | |||||
Cases | 0.031 | 0.025 | 0.169 | 0.008 | 0.0005 |
Non-cases | 0.053 | 0.026 | 0.044 | 0.001 | 0.469 |
0.088 | 0.036 | 0.016 | 0.006 | 0.018 | |
FRS+FH+GRS1 | |||||
Cases | 0.065 | 0.035 | 0.065 | 0.006 | 0.0065 |
Non-cases | 0.033 | 0.031 | 0.033 | 0.001 | 0.588 |
0.098 | 0.042 | 0.019 | 0.007 | 0.003 | |
FRS+FH+GRS2 | |||||
Cases | 0.142 | 0.041 | 0.0005 | 0.018 | 0.001 |
Non-cases | 0.011 | 0.039 | 0.787 | 0.001 | 0.683 |
0.132 | 0.054 | 0.015 | 0.018 | 0.0025 |
Reclassification results comparing a baseline model including family history (FH); to models including genetic risk scores for men aged 50–59.