Table 1. Metabolic parameters of C57Bl/6 mice fed a low or high fat diet for 12 wk.
| LFD | HFD | |
| Body mass (g) | 30.3±1.2 | 38.1±1.0b |
| Lean mass (g) | 25.6±1.0 | 25.1±0.5 |
| Fat mass (g) | 3.9±0.4 | 12.1±0.8b |
| % lean mass | 84.5±1.0 | 66.0±1.6b |
| % fat mass | 13.0±1.4 | 31.6±1.5 |
| Epididymal fat pad (g) | 0.63±0.04 | 1.97±0.10b |
| Subcutaneous fat pad (g) | 0.42±0.04 | 1.58±0.13b |
| Blood glucose (mM) | 8.5±0.4 | 9.4±0.5a |
| Plasma insulin (pM) | 62.1±10.7 | 401.0±94.0b |
| HOMA-IR | 3.0±0.5 | 22.5±5.5a |
| Plasma free fatty acids (mM) | 0.66±0.08 | 0.62±0.06 |
| Plasma triglycerides (mM) | 0.80±0.10 | 0.97±0.07 |
All measurements were made in 5 hour fasted mice. Data are mean ± SEM.
a
P<0.05 vs Chow;
b
P<0.001 vs Chow. LFD, low fat diet; HFD, high fat diet.