Table 1. Meta-analytically cut-point comparison of the joint sensitivity and specificity of cervical and anal cytology for biopsy confirmed high grade dysplasia.
| Sensitivity (SE) | Specificity (SP) | |||||||
| Cytology Cut-Point | Anal | Cervical | Anal | Cervical | ||||
| SE | (95% CI) | SE | (95% CI) | SP | (95% CI) | SP | (95% CI) | |
| (HSIL or ASC-H) vs. (LSIL, ASCUS, Normal)1 | 0.30 | (0.19–0.44) | 0.63 | (0.56–0.69) | 0.93 | (0.90–0.95) | 0.96 | (0.95–0.98) |
| (HSIL or ASC-H, LSIL) vs. (ASCUS, Normal)2 | 0.73 | (0.62–0.82) | 0.80 | (0.75–0.85) | 0.55 | (0.45–0.65) | 0.76 | (0.66–0.83) |
| (HSIL or ASC-H, LSIL, ASCUS) vs. (Normal)3 | 0.90 | (0.76–0.96) | 0.91 | (0.88–0.94) | 0.33 | (0.20–0.49) | 0.53 | (0.40–0.66) |
1. Joint model comparison (cervical vs. anal): p<0.001; I2 = 92.
2. Joint model comparison (cervical vs. anal): p<0.001; I2 = 82.
3. Joint model comparison (cervical vs. anal: p = 0.04; I2 = 68.
CI = Confidence Interval, HSIL = High grade squamous intraepithelial lesion, ASC-H = Atypical squamous cells can’t rule out high grade, LSIL = Low grade squamous intraepithelial lesion, ASCUS = Atypical squamous cells of uncertain significance.