Table 1. Enrichment of functional features in MI clusters and MI3D clusters.

	MI clusters	MI3D clusters	catalytic MI3D clusters	non-catalytic MI3D clusters
	Odds ratio	Odds ratio	Odds ratio	Odds ratio
ACT_SITE	1.345*	1.341*	2.457*	0.141*
BINDING	1.312*	1.428*	2.431*	0.446
METAL	1.333*	2.210*	3.292*	0.166
SITE	1.237	1.264	3.011	0.403
MUTAGEN	1.652*	1.931*	2.754*	–
MOD_RES	1.200	0.982	1.527	0.032

Enrichment (average odds-ratio) of functional features in MI clusters, MI3D clusters, catalytic MI3D clusters and non-catalytic MI3D clusters. Stars indicate statistical significance at α = 0.01 (Fisher’s exact test).