Table 2. Differentially methylated probes for each cell population in comparison to whole blood.

	M-value comparison	Comparison on calls*	Absolute variation in comparison to whole blood (M-values)**	Unmethylated	Marginal	Methylated
PBMC	23226	5693	1.2–11.1	1.7%	25.8%	72.5%
CD4+ T-cells	58980	18537	1.2–51.9	9.4%	34.5%	56.1%
CD8+ T-cells	125713	32948	1.2–93.2	6.8%	59.7%	33.4%
CD56+ NK cells	92238	23484	1.1–54.0	6.5%	58.4%	35.1%
CD19+ B cells	97377	23245	1.2–221.8	15.0%	55.7%	29.3%
CD14+ Monocytes	41063	12625	1.2–70.4	71.2%	13.2%	15.6%
Granulocytes	27365	8815	1.2–13.1	85.3%	9.5%	5.2%
Neutrophils	28581	10808	1.2–14.5	84.2%	10.1%	5.7%
Eosinophils	52431	17723	1.2–117.2	65.8%	23.3%	10.8%

PBMC-Peripheral blood mononuclear cells. Differentially methylated probes were defined by a linear model using the M-values. M-value is the log2 ratio of the intensities of methylated probe versus unmethylated probe, a measurement of how much more a probe is methylated compared to unmethylated [46]. *To extract the probes with largest difference in methylation, a gamma fit model was applied to M-values in order to define the three calls: “unmethylated”, “marginal” and “methylated”. Significant probes sharing the same call in the two compared populations were removed. **Variation is based on the estimate of the log2-fold-change corresponding to the effect obtained from the linear model, absolute M-values are presented. The percentages are based on the call distribution.