Skip to main content
. Author manuscript; available in PMC: 2012 Jul 25.
Published in final edited form as: Science. 2011 Aug 26;333(6046):1109–1112. doi: 10.1126/science.1201940

Figure 1. Interactions between mitochondria, cell death, autophagy, and inflammation in young individuals (a) and during aging (b).

Figure 1

In this scenario, loss of autophagy with age leads to accumulation of damaged mitochondria, which promote cell death and inflammation, both of which are otherwise limited by autophagy.