FIG. 2.

Characterization of Fbn1^CMV−/− mice. (a) Survival curves showing the percent survival of various mice in days after birth with indicated the number (n) of animals for each genotype. Fbn1^+/+and Fbn1^CMV−/− curves are not significantly different from each other (p>0.1). (b) Bar graphs summarizing qPCR analyses of Fbn1 transcripts in neonatal lungs (white, Fbn1^+/+ mice; black, Fbn1^CMV−/− mice). Data are from 3 independent samples of each genotype assayed in triplicate and including ± SE. (c) Anatomy of aortas collected from P16 Fbn1^+/+ and Fbn1^CMV−/−mice showing a large dilation (arrowhead) in the latter sample. (c) Illustrative cross-section image of a dilated ascending aorta of Fbn1^CMV−/− mice demonstrating a tear through the aortic wall with a large thrombus (between arrows); image taken at 4X.