Table 2.

Uptake of [3H]-Riboflavin on RBE4 cells in presence of various concentrations of Ca⁺⁺/calmodulin pathway and PKA modulators in DPBS (pH 7.4) at 37° C. The uptake is expressed as percentage of control (DPBS). Each data point is expressed as mean ± standard deviation (n=4). P<0.01 is considered as statistically significant from control. NS represents not statistically significant from control.

Pathway	Modulators	Uptake as % of control	Statistics
Ca++/ Calmodulin	Control Cal (10 µM) Cal (25 µM) Cal (50 µM) Cal (100 µM) Cal (250 µM) KN-62 (10 µM) KN-62 (25 µM) KN-62 (50 µM) TFP (100 µM) TFP (250 µM)	100 ± 4 105 ± 6 91 ± 1 65 ± 3 55 ± 3 38 ± 5 80 ± 2 67 ± 2 69 ± 5 70 ± 3 65 ± 6	- NS NS P<0.01 P<0.01 P<0.01 P<0.01 P<0.01 P<0.01 P<0.01 P<0.01
PKA	Control FOR (50 µM) FOR (100 µM) IBMX (2.5 mM) IBMX (5 mM)	100 ± 10 85 ± 3 67 ± 2 61 ± 3 50 ± 3	- P<0.01 P<0.01 P<0.01 P<0.01