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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Nat Mater. 2012 Jul 1;11(8):734–741. doi: 10.1038/nmat3361

Fig. 4. 3D fibrin-gel cultured B16-F1 cells do not stiffen but elevate tractions with substrate rigidity.

Fig. 4

(a) Cell stiffness (shear modulus) as a function of substrate stiffness. 3D fibrin gel cultured B16-F1 cells do not stiffen much with substrate rigidity, whereas control cancer cells do. Mean ± s.e.m., 5 independent experiments; at least 150 cells per experiment. (b) Both 3D fibrin gel cultured B16-F1 cells and control cells elevate tractions on stiffer substrates. The cells were plated for 6 hr before experiments in both (a) and (b). Mean ± s.e.m.; 3 independent experiments, n> 60 cells for each value (**, p<0.01; ***, p<0.001.)