Table 2. p16 expression by smoking status and tumour site.
| p16 Expression | HN | HC | LS |
|---|---|---|---|
| Smokers | |||
| HPV negative | 4 (1 OC, 3 OP) | 14 (5 OC, 1 LA, 3 HY, 5 OP) | 92 (40 OC,33 LA, 3 HY, 16 OP) |
| HPV positive | 3 (OP) | 8 (OP) | 2 (1 OC, 1OP) |
| Nonsmokers | |||
| HPV negative | 2 (OP) | 1(OC) | 6 (5 OC, 1 OP) |
| HPV positive | 0 | 2 (OP) | 1 (1 OC) |
Abbreviations: HC=high cytoplasmic, low nuclear staining; HN=high nuclear, any cytoplasmic staining; HPV=human papillomavirus; HY=hypopharynx; LA=larynx; LS=low nuclear, low cytoplasmic staining; OC=oral cavity; OP=oropharynx.