Table 1.
Data analysis of the microarray results reveals genes that are most up- and down-regulated by Isx-9
| Gene | Symbol | Function | Fold change, Isx-9 vs. control |
|---|---|---|---|
| Actin, α2, aorta | Acta2 | Structural protein; cytoskeleton, cell motility | +4.96 |
| Friend leukemia integration 1 | Fli1 | Transcription factor; epithelia, heart development | +4.95 |
| Zinc finger protein of the cerebellum 3 | Zic3 | Transcription factor; CNS and muscle development | +4.95 |
| Interleukin 2 receptor, γ chain | Il2rg | Internalization receptor; increases cyclin D2 expression, cell proliferation | +4.35 |
| Cadherin 5 | Cdh5 | Adhesion protein; Ca2+-dependent adherence junction | +4.35 |
| Synapsin II | Syn2 | Synaptic vesicle release | −2.33 |
| Cyclin M4 | Cnnm4 | Membrane metal ion transport | −2.36 |
| Transforming growth factor β3 | Tgfb3 | Cell signaling; antiproliferative, stops cell cycle at G1 | −2.65 |
| Zinc finger, H2C2 domain containing | Zh2c2 | DNA binding protein; gene expression in neurons | −2.87 |
| Kinesin family member 2C | Kif2c | Motor protein; dendritic growth | −3.81 |
Table shows the fold change in gene expression, gene name, and abbreviation, and some important gene functions.