Figure 2.
SIK1 mediates the effect of LKB1 on E-cadherin. A) Expression (mRNA) of E-cadherin in MLE-12 cells transiently (48 and 72 h) expressing SIK1 wild-type (open bars) and SIK1 lacking the LKB1-phosphorylation (T182A) site (solid bars). B) Expression (mRNA) of Snail2 in MLE-12 cells transiently (48 and 72 h) expressing SIK1 wild-type and SIK1 lacking the T182A site. Values are expressed as percentage increase vs. cells expressing the empty vector. Bars represent means ± se of 4-6 experiments.