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. 2012 Aug;26(8):3230–3239. doi: 10.1096/fj.12-205609

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Figure 5. — Effects of SIK1 on transepithelial resistance and ion transporter activities. A) TER was determined in MLE-12 cells expressing (sc-shRNA) and lacking (SIK1-shRNA) SIK1 grown on permeable support for 5 d. Recordings were monitored daily in 6 independent cell preparations in each group. B) TER measured in sc-shRNA (solid circles) and SIK1-shRNA (open circles) MLE-12 cells grown on permeable support. Recordings were monitored in 6 independent cell preparations at time points indicated. Arrows indicate the presence or absence of calcium in the incubation medium. C) TER in MDCK (dog renal distal tubule; right panel) and in T84 (intestinal; left panel) cells with (sc-siRNA) and without a transient reduction (SIK1-siRNA) in SIK1 protein levels. Cells were grown on permeable support for 5 d. Recordings were monitored daily in 6 independent cell preparations in each group. MDCK data represent recordings performed at day 3. *P < 0.05.