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. Author manuscript; available in PMC: 2013 Jun 13.
Published in final edited form as: Nano Lett. 2012 May 31;12(6):3322–3328. doi: 10.1021/nl301529p

Figure 1.

Figure 1

(A) Controlled cellular uptake by modulation of local Arg density is achieved by temperature-triggered micelle assembly of a genetically encoded Arg5-ELPBC. (B) `Off state': At 37 °C, below the CMT, Arg5-ELPBCs exist as soluble unimers, whose limited number of Arg residues is below the threshold necessary for efficient cellular uptake. `On state': Above the CMT at 42 °C (a temperature that can be achieved with mild clinical hyperthermia) Arg5-ELPBCs assemble into spherical micelles. The high density of Arg decorating the micelle corona exceeds the threshold of Arg residues necessary for internalization, leading to cellular uptake of the micelles.